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TRNAMet cytidine acetyltransferase

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TRNAMet cytidine acetyltransferase
Identifiers
EC no.2.3.1.193
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
PubMedarticles
NCBIproteins

TRNAMet cytidine acetyltransferase (EC 2.3.1.193, YpfI, TmcA) is an enzyme with systematic name acetyl-CoA:(elongator tRNAMet)-cytidine34 N4-acetyltransferase (ATP-hydrolysing).[1][2] This enzyme catalyses the following chemical reaction

[elongator tRNAMet]-cytidine34 + ATP + acetyl-CoA CoA + [elongator tRNAMet]-N4-acetylcytidine34 + ADP + phosphate

The enzyme acetylates the wobble base C34 of the CAU anticodon of elongation-specific tRNAMet.

References

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  1. ^ Ikeuchi Y, Kitahara K, Suzuki T (August 2008). "The RNA acetyltransferase driven by ATP hydrolysis synthesizes N4-acetylcytidine of tRNA anticodon". The EMBO Journal. 27 (16): 2194–203. doi:10.1038/emboj.2008.154. PMC 2500205. PMID 18668122.
  2. ^ Chimnaronk S, Suzuki T, Manita T, Ikeuchi Y, Yao M, Suzuki T, Tanaka I (May 2009). "RNA helicase module in an acetyltransferase that modifies a specific tRNA anticodon". The EMBO Journal. 28 (9): 1362–73. doi:10.1038/emboj.2009.69. PMC 2683049. PMID 19322199.
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